产品货号：
Z22988
中文名称：
PDCD5抗体
英文名称：
Anti-PDCD5 antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PDCD5 antibody |
| 指标别名 | PDCD5;programmed cell death 5;Protein TFAR19;TFAR19 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | PDCD5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human PDCD5 recombinant protein (Position:M1-D120). |
| 实际分子量 | 14KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Programmed cell death 5 (PDCD5),a human apoptosis-related protein,is thought to play an early and universal role in apoptosis.PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis,where it translocates rapidly from the cytoplasm to the nucleus.PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region.The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein.PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death.PDCD5 may play a dual role in the Tip60 pathway.It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis.The nucleotide polymorphisms in the 5'-upstream region of?PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer. |
| Uniprot ID | O14737 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | programmed cell death 5 |
| 蛋白名全称 | Programmed cell death protein 5 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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